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PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation
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PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation
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Journal Article
PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation
2015
Overview
Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood. In this study, using loss-of-function studies
in vitro
and
in vivo
, we show that the anti-apoptotic protein poly(ADP-ribose) polymerase (PARP)14 promotes aerobic glycolysis in human hepatocellular carcinoma (HCC) by maintaining low activity of the pyruvate kinase M2 isoform (PKM2), a key regulator of the Warburg effect. Notably, PARP14 is highly expressed in HCC primary tumours and associated with poor patient prognosis. Mechanistically, PARP14 inhibits the pro-apoptotic kinase JNK1, which results in the activation of PKM2 through phosphorylation of Thr365. Moreover, targeting PARP14 enhances the sensitization of HCC cells to anti-HCC agents. Our findings indicate that the PARP14-JNK1-PKM2 regulatory axis is an important determinant for the Warburg effect in tumour cells and provide a mechanistic link between apoptosis and metabolism.
Tumour cells can survive by evading cell death pathways and altering their metabolism to adapt to their local environment. In this study, Iansante
et al
. show that the anti-apoptotic protein PARP14 maintains low PKM2 activity, leading to enhanced glycolysis, demonstrating a link between suppression of apoptosis and altered metabolism.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/89
/ 13/95
/ 96
/ 96/2
/ Carcinoma, Hepatocellular - metabolism
/ Carrier Proteins - metabolism
/ Enzymes
/ Glucose
/ Humanities and Social Sciences
/ Humans
/ Kinases
/ Liver Cirrhosis - metabolism
/ Liver Neoplasms - metabolism
/ Membrane Proteins - metabolism
/ Mitogen-Activated Protein Kinase 8 - metabolism
/ Patients
/ Poly(ADP-ribose) Polymerases - metabolism
/ Proteins
/ Ribose
/ Science
/ Thyroid Hormone-Binding Proteins
/ Thyroid Hormones - metabolism
/ Tumors
