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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
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Journal Article
Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
2014
Overview
The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (
P
<5 × 10
−8
) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to
VTI1A
;
P
=1.4 × 10
−9
), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide and genetic susceptibility to the disease is poorly understood. Here, the authors combine data from Japanese, African American and European samples and identify a common variant in
VTI1A
that increases CRC risk across all populations.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Alleles
/ Black or African American - genetics
/ Colorectal Neoplasms - ethnology
/ Colorectal Neoplasms - genetics
/ Genetic Predisposition to Disease
/ Genome-Wide Association Study
/ Genotype
/ Humanities and Social Sciences
/ Humans
/ Japan
/ Polymorphism, Single Nucleotide
/ Qb-SNARE Proteins - genetics
/ Science
