Journal Article

Synchronous versus metachronous spinal metastasis: a comparative study of survival outcomes following neurosurgical treatment

Gielen, Gerrit H., Banat, Mohammed, Nitsch, Louisa, Scorzin, Jasmin E., Khalafov, Logman, Asoglu, Harun, Borger, Valeri, Radbruch, Alexander, Schmeel, Frederic C., Lampmann, Tim, Potthoff, Anna-Laura, Hamed, Motaz, Paech, Daniel, Schneider, Matthias, Weller, Johannes, Herrlinger, Ulrich, Toma, Marieta, Vatter, Hartmut

2024

Overview

Purpose Patients with spinal metastases (SM) from solid neoplasms typically exhibit progression to an advanced cancer stage. Such metastases can either develop concurrently with an existing cancer diagnosis (termed metachronous SM) or emerge as the initial indication of an undiagnosed malignancy (referred to as synchronous SM). The present study investigates the prognostic implications of synchronous compared to metachronous SM following surgical resection. Methods From 2015 to 2020, a total of 211 individuals underwent surgical intervention for SM at our neuro-oncology facility. We conducted a survival analysis starting from the date of the neurosurgical procedure, comparing those diagnosed with synchronous SM against those with metachronous SM. Results The predominant primary tumor types included lung cancer (23%), prostate cancer (21%), and breast cancer (11.3%). Of the participants, 97 (46%) had synchronous SM, while 114 (54%) had metachronous SM. The median overall survival post-surgery for those with synchronous SM was 13.5 months (95% confidence interval (CI) 6.1–15.8) compared to 13 months (95% CI 7.7–14.2) for those with metachronous SM ( p  = 0.74). Conclusions Our findings suggest that the timing of SM diagnosis (synchronous versus metachronous) does not significantly affect survival outcomes following neurosurgical treatment for SM. These results support the consideration of neurosurgical procedures regardless of the temporal pattern of SM manifestation.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Breast cancer / breast neoplasms / Cancer / Cancer Research / comparative study / confidence interval / Diagnosis / Hematology / Humans / Internal Medicine / Lung cancer / lung neoplasms / Lung Neoplasms - pathology / Male / Malignancy / Medicine / Medicine & Public Health / Metastases / Metastasis / Neoplasm Staging / Neoplasms, Multiple Primary - pathology / Neoplasms, Second Primary - pathology / Neurosurgery / Oncology / Prognosis / Prostate cancer / prostatic neoplasms / resection / Retrospective Studies / Spinal Neoplasms - pathology / Spinal Neoplasms - surgery / Survival / Survival Analysis