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Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features
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Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features
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Journal Article
Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features
2019
Overview
Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis. Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms with peculiar molecular and pathological features; the diagnosis of these neoplasms may be challenging, due to wide differential diagnosis depending to the variable anatomical location. The authors summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
/ Age
/ extragonadal germ cell tumors
/ Gonads
/ Humans
/ Males
/ Neoplasms, Germ Cell and Embryonal - epidemiology
/ Neoplasms, Germ Cell and Embryonal - metabolism
/ Neoplasms, Germ Cell and Embryonal - pathology
/ Neoplasms, Germ Cell and Embryonal - therapy
/ Review
/ SALL4
/ seminoma
/ SOX2
/ teratoma
/ Tumors
