Journal Article

Initial reports of the SARS‐CoV‐2 Delta variant (B.1.617.2 lineage) in Bangladeshi patients: Risks of cross‐border transmission from India

Rahman, M. Shaminur, Islam, Ovinu Kibria, Islam, Md. Tanvir, Sarkar, Shovon Lal, Hasan, Md. Shazid, Hossain, M. Anwar, Setu, Md. Ali Ahsan, Alam, A. S. M. Rubayet Ul, Jahid, Iqbal Kabir, Chakrovarty, Tanay, Al‐Emran, Hassan M.

2021

Overview

Medical report of the male patient Blood group ABO B Rh Positive Hematological report HGB (Hemoglobin) (cyanomethanoglobin method) 13.0 g/dL ESR (westergren) 35 mm Differential count WBC Total count of WBC 5300/cmm Neutrophils 43% Lymphocytes 48% Eosinophils 3% Monocytes 6% Basophils 0% Total count of platelet 210 000/cmm Biochemical analysis report Random plasma glucose 5.8 mmol/L S. Creatinine 0.9 mg/dL SGPT (ALT) 32 U/L Immunology report D-Dimer 0.21 Case 2: Medical report of the female patient Hematological report HGB (hemoglobin) (cyanomethanoglobin method) 11.5 g/dL ESR (westergren) 20 mm Differential count WBC Total count of WBC 8200/cmm Neutrophils 57% Lymphocytes 35% Eosinophils 6% Monocytes 2% Basophils 0% Total count of platelet 1,86 000/cmm Biochemical analysis report S. Bilirubin 0.8 mg/dL SGPT (ALT) 32 U/L SGOT (AST) 45 Immunology report D-Dimer Not done Partial sequencing of the RBD portion of the spike protein revealed two featured mutations (L452R and T478K) of the B.1.617.2 PANGO lineage for both samples. 14 Whole-genome sequences revealed 38 mutations and 29 aa substitutions for the sample JUST1 (Collected from the female patient, GISAID accession ID—EPI_ISL_ 2 036 272) and 33 mutations and 26 aa substitutions for sample JUST2 (Collected from the male patient, GISAID accession ID—EPI_ISL_1942249). [...]the Nextstrain server (https://nextstrain.org/sars-cov-2/) for SARS-CoV-2 phylodynamics also bolstered our interpretation based on the mutation pattern of the strains. The Delta variants were 50% more transmissible and 60% more lethal (For every one death 1.6 death in ratio compared with the previous version of the virus) with reduced affinity for neutralizing antibody (The L452R mutation confers a reduction of the recognition capability of the immune system) as demonstrated by other studies. 15,16 Transmission of these new variants may cause a similar impact among Bangladeshi population, which introduced the Oxford-Astrazeneca vaccine.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
• Subject: Amino acids / Coronaviruses / COVID-19 diagnostic tests / COVID-19 vaccines / Creatinine / Disease transmission / Genomes / Hematology / Hemoglobin / Hospitals / Immunology / Mutation / Neutrophils / Patients / Research Letter / Research Letters / Severe acute respiratory syndrome coronavirus 2 / Travel / Whole genome sequencing