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Neutrophils scan for activated platelets to initiate inflammation

by Moro, María A. , Filippi, Marie-Dominique , Zarbock, Alexander , McEver, Rodger P. , Rossaint, Jan , Ballesteros, Ivan , Radovanovic, Irena , Hidalgo, Andrés , Adrover, José M. , Nácher, Maria , Ruiz-Cabello, Jesús , Lizasoain, Ignacio , Fukui, Yoshinori , Cuartero, Maria Isabel , Sreeramkumar, Vinatha , Pitaval, Christophe , Bilbao, Izaskun

in Acute lung injury / Animals / Blood Circulation / Blood platelets / Blood Platelets - immunology / Cell Movement / Cell Polarity / Endothelium, Vascular - immunology / Immune system / Inflammation / Inflammation - blood / Inflammation - immunology / Leukocytes / Male / Membrane Glycoproteins / Mice / Mice, Inbred C57BL / Morphology / Neutrophil infiltration / Neutrophils / Neutrophils - immunology / Platelet Activation / Platelets / Quantification / Receptors / Signal Transduction / Thrombosis - immunology / Venules / Venules - immunology

2014

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Neutrophils scan for activated platelets to initiate inflammation

2014

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2014

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Journal Article

Neutrophils scan for activated platelets to initiate inflammation

Moro, María A.,

Filippi, Marie-Dominique,

Zarbock, Alexander,

McEver, Rodger P.,

Rossaint, Jan,

Ballesteros, Ivan,

Radovanovic, Irena,

Hidalgo, Andrés,

Adrover, José M.,

Nácher, Maria,

Ruiz-Cabello, Jesús,

Lizasoain, Ignacio,

Fukui, Yoshinori,

Cuartero, Maria Isabel,

Sreeramkumar, Vinatha,

Pitaval, Christophe,

Bilbao, Izaskun

2014

Overview

Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream.The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution of receptors that drive neutrophil migration. Consequently, neutrophils unable to polarize or to transduce signals through PSGL-1 displayed aberrant crawling, and blockade of this domain protected mice against thromboinflammatory injury. These results reveal that recruited neutrophils scan for activated platelets, and they suggest that the neutrophils' bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Acute lung injury

/ Animals

/ Blood Circulation

/ Blood platelets

/ Blood Platelets - immunology

/ Cell Movement

/ Cell Polarity