Asset Details
Do you wish to reserve the book?
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
Do you wish to request the book?
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
2019
Overview
The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of β-amyloid (Aβ) that accumulates in Alzheimer’s disease (AD). Furthermore, chronic sleep deprivation (SD) increases Aβ plaques. However, tau, not Aβ, accumulation appears to drive AD neurodegeneration. We tested whether ISF/CSF tau and tau seeding and spreading were influenced by the sleep-wake cycle and SD. Mouse ISF tau was increased ~90% during normal wakefulness versus sleep and ~100% during SD. Human CSF tau also increased more than 50% during SD. In a tau seeding-and-spreading model, chronic SD increased tau pathology spreading. Chemogenetically driven wakefulness in mice also significantly increased both ISF Aβ and tau. Thus, the sleep-wake cycle regulates ISF tau, and SD increases ISF and CSF tau as well as tau pathology spreading.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Amyloid beta-Peptides - analysis
/ Amyloid beta-Peptides - cerebrospinal fluid
/ Amyloid beta-Peptides - metabolism
/ Animals
/ Brain
/ Extracellular Fluid - chemistry
/ Extracellular Fluid - metabolism
/ Female
/ Male
/ Mice
/ Proteins
/ Sleep
/ Sleep Deprivation - cerebrospinal fluid
/ Sleep Deprivation - metabolism
/ Spires
