Journal Article

Construction of a Diagnostic Prediction Model for Feline Nasal and Nasopharyngeal Diseases in Japan Using Noninvasive Examinations

Takeuchi, Yoshinori, Goto, Sho, Ino, Masatoshi, Kanemoto, Hideyuki, Hamamoto, Yuji, Ohshima, Takafumi, Fujiwara‐Igarashi, Aki, Nakazawa, Yuta

2025

Overview

Background Although feline nasal and nasopharyngeal diseases (NNDs) often require advanced tests under general anaesthesia for definitive diagnosis, not all patients can undergo them. Objectives This study aimed to construct diagnostic prediction models for feline NNDs in Japan using noninvasive examinations, signalment and history. Methods Seventy‐nine cats diagnosed with NNDs, including representative diseases in Japan—nasal and nasopharyngeal tumours (NNT), rhinitis (RS) and nasopharyngeal stenosis (NPS)—were retrospectively investigated to construct prediction models (model group, GM). Thirty‐nine cats diagnosed were prospectively investigated to validate their efficacy (validation group, GV). Three predictive models were developed: Models 1 and 2 were manually constructed, with Model 1 designed to predict NNT, RS and NPS individually and Model 2 distinguishing between these diseases. Model 3 was constructed using least absolute shrinkage and selection operator logistic regression. Sensitivity, indicating the ability to identify cases of each disease, and specificity, reflecting the ability to exclude other diseases, were used to assess performance. Results In Model 1 of the GV, the sensitivity and specificity for NNT, RS and NPS were 1.00 and 0.73, 0.62 and 0.96 and 0.78 and 0.97, respectively. In Model 2 of the GV, the values were 0.94 and 0.86 for NNT, 0.77 and 0.92 for RS and 0.75 and 0.94 for NPS. In Model 3 of the GV, they were 0.94 and 0.05 for NNT, 0.25 and 1.00 for RS and 0.13 and 0.84 for NPS. Conclusions The diagnostic prediction models, particularly Models 1 and 2, could help estimate whether advanced tests are necessary. This study aimed to construct a diagnostic prediction model for feline nasal and nasopharyngeal diseases (NNDs) representative in Japan as nasal and nasopharyngeal tumours, rhinitis and nasopharyngeal stenosis using noninvasive examinations, signalment and history. A total of 79 cats diagnosed with NND were retrospectively investigated to construct the 3 types of prediction models, and 39 cats diagnosed were prospectively investigated to validate their efficacy. The diagnostic prediction models, particularly Models 1 and 2, could help estimate whether advanced tests are necessary.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
• Subject: Age / Anesthesia / Animal models / Animals / Biopsy / Cat Diseases - diagnosis / Cats / Deformities / diagnostic prediction model / Disease / Endoscopy / Epistaxis / Female / Foreign bodies / General anesthesia / Japan / Magnetic resonance imaging / Male / nasal and nasopharyngeal diseases / nasal and nasopharyngeal tumour / Nasopharyngeal Diseases - diagnosis / Nasopharyngeal Diseases - veterinary / nasopharyngeal stenosis / Nose Diseases - diagnosis / Nose Diseases - veterinary / Original / Polyps / Prediction models / Retrospective Studies / Rhinitis / Rhinitis - diagnosis / Rhinitis - veterinary / Sensitivity and Specificity / Stenosis / Tumors / Veterinary medicine