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Vaccination with Clumping Factor A and Fibronectin Binding Protein A to Prevent Staphylococcus aureus Infection of an Aortic Patch in Mice
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Vaccination with Clumping Factor A and Fibronectin Binding Protein A to Prevent Staphylococcus aureus Infection of an Aortic Patch in Mice
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Journal Article
Vaccination with Clumping Factor A and Fibronectin Binding Protein A to Prevent Staphylococcus aureus Infection of an Aortic Patch in Mice
2008
Overview
Staphylococcus aureus is a leading cause of ventricular assist device-related infections. This study evaluated the protective effect against S. aureus infection of active and passive immunization that targeted 3 proteins involved in bacterial attachment to a murine intra-aortic polyurethane patch. Active immunization of mice with a combination of the A domains of clumping factor A (ClfA), fibronectin-binding protein A (FnBPA) and fibronectin-binding protein B or passive immunization with monoclonal antibodies against ClfA and FnBPA resulted in a higher level of protection than that obtained by vaccination with either protein or antibody alone. The combination of antibodies or protein antigens appears to provide enhanced protection against prosthetic-device infection.
Publisher
The University of Chicago Press,University of Chicago Press
Subject
Adhesins, Bacterial - administration & dosage
/ Adhesins, Bacterial - immunology
/ Animals
/ Antigens
/ Aorta
/ Bacteria
/ Bacterial Vaccines - administration & dosage
/ Bacterial Vaccines - chemistry
/ Biological and medical sciences
/ Coagulase - administration & dosage
/ Endocarditis, Bacterial - metabolism
/ Endocarditis, Bacterial - microbiology
/ Endocarditis, Bacterial - pathology
/ Fundamental and applied biological sciences. Psychology
/ Mice
/ Staphylococcal Infections - immunology
