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Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
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Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
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Journal Article
Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
2021
Overview
The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.
Publisher
MDPI AG,MDPI
Subject
/ Bacteria
/ Biofilms
/ Colonic Neoplasms - diagnosis
/ Colonic Neoplasms - pathology
/ E coli
/ Female
/ Histiocytoma, Malignant Fibrous
/ Histiocytoma, Malignant Fibrous - diagnosis
/ Histiocytoma, Malignant Fibrous - pathology
/ Humans
/ Indium
/ Male
/ Mammary Neoplasms, Animal - diagnosis
/ Mammary Neoplasms, Animal - pathology
/ Mice
/ Prostatic Neoplasms - diagnosis
/ Prostatic Neoplasms - diagnostic imaging
/ Prostatic Neoplasms - pathology
/ Prostatitis - diagnostic imaging
/ Selenium
/ Silver
/ Staphylococcus aureus - isolation & purification
/ Staphylococcus aureus - pathogenicity
/ Sulfides
/ Toxicity
/ Water
