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Comparative transcriptomics gives insights into the evolution of parasitism in Strongyloides nematodes at the genus, subclade and species level
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Comparative transcriptomics gives insights into the evolution of parasitism in Strongyloides nematodes at the genus, subclade and species level
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Journal Article
Comparative transcriptomics gives insights into the evolution of parasitism in Strongyloides nematodes at the genus, subclade and species level
2018
Overview
Strongyloides
spp., gastrointestinal nematode parasites of humans and other animals, have genetically identical parasitic and free-living adult life cycle stages. This is an almost unique feature amongst nematodes and comparison of these two stages can provide insights into the genetic basis and evolution of
Strongyloides
nematode parasitism. Here, we present RNAseq data for
S
.
venezuelensis
, a parasite of rodents, and identify genes that are differentially expressed in parasitic and free-living life cycle stages. Comparison of these data with analogous RNAseq data for three other
Strongyloides
spp., has identified key protein-coding gene families with a putative role in parasitism including WAGO-like Argonautes (at the genus level) and speckle-type POZ-like coding genes (
S
.
venezuelensis-S
.
papillosus
phylogenetic subclade level). Diverse gene families are uniquely upregulated in the parasitic stage of all four
Strongyloides
species, including a distinct upregulation of genes encoding cytochrome P450 in
S
.
venezuelensis
, suggesting some diversification of the molecular tools used in the parasitic life cycle stage among individual species. Together, our results identify key gene families with a putative role in
Strongyloides
parasitism or features of the parasitic life cycle stage, and deepen our understanding of parasitism evolution among
Strongyloides
species.
Publisher
Nature Publishing Group UK,Nature Publishing Group
