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Maternal Antibody and Viral Factors in the Pathogenesis of Dengue Virus in Infants

by Hien, Tran Tinh , Chau, Tran Nguyen Bich , Thuy, Tran Thi , Whitehead, Steve , Farrar, Jeremy , Lien, Le Bich , Hoang, Dang Minh , McElnea, Catriona , Simmons, Cameron P. , Quy, Nguyen Thien , Young, Paul , Thien, Nguyen Thanh , Tuan, Nguyen Minh , Hieu, Nguyen Trong , Hung, Nguyen Thanh

in Antibodies / Antibodies, Viral / Antigens, Viral - blood / Biological and medical sciences / Blood plasma / Dengue / Dengue - immunology / Dengue hemorrhagic fever / Dengue virus / Dengue Virus - classification / Dengue Virus - immunology / Diseases / Female / Fundamental and applied biological sciences. Psychology / Humans / Immunity, Maternally-Acquired / Infant / Infants / Infections / Male / Microbiology / Miscellaneous / Neutralization Tests / Pathogenesis / Time Factors / Viral Load / Viremia / Virology / Viruses

2007

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Maternal Antibody and Viral Factors in the Pathogenesis of Dengue Virus in Infants

2007

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2007

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Journal Article

Maternal Antibody and Viral Factors in the Pathogenesis of Dengue Virus in Infants

Hien, Tran Tinh,

Chau, Tran Nguyen Bich,

Thuy, Tran Thi,

Whitehead, Steve,

Farrar, Jeremy,

Lien, Le Bich,

Hoang, Dang Minh,

McElnea, Catriona,

Simmons, Cameron P.,

Quy, Nguyen Thien,

Young, Paul,

Thien, Nguyen Thanh,

Tuan, Nguyen Minh,

Hieu, Nguyen Trong,

Hung, Nguyen Thanh

2007

Overview

The pathogenesis of dengue in infants is poorly understood. We postulated that dengue severity in infants would be positively associated with markers of viral burden and that maternally derived, neutralizing anti-dengue antibody would have decayed before the age at which infants with dengue presented to the hospital. In 75 Vietnamese infants with primary dengue, we found significant heterogeneity in viremia and NS1 antigenemia at hospital presentation, and these factors were independent of disease grade or continuous measures of disease severity. Neutralizing antibody titers, predicted in each infant at the time of their illness, suggested that the majority of infants (65%) experienced dengue hemorrhagic fever when the maternally derived neutralizing antibody titer had declined to <1:20. Collectively, these data have important implications for dengue vaccine research because they suggest that viral burden may not solely explain severe dengue in infants and that neutralizing antibody is a reasonable but not absolute marker of protective immunity in infants.

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Publisher

The University of Chicago Press,University of Chicago Press

Subject

Antibodies

/ Antibodies, Viral

/ Antigens, Viral - blood

/ Biological and medical sciences

/ Blood plasma

/ Dengue

/ Dengue - immunology