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Cytogenetic analysis delineates a spectrum of chromosomal changes that can distinguish non-MALT marginal zone B-cell lymphomas among mature B-cell entities: a description of 103 cases
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Cytogenetic analysis delineates a spectrum of chromosomal changes that can distinguish non-MALT marginal zone B-cell lymphomas among mature B-cell entities: a description of 103 cases
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Cytogenetic analysis delineates a spectrum of chromosomal changes that can distinguish non-MALT marginal zone B-cell lymphomas among mature B-cell entities: a description of 103 cases
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Journal Article
Cytogenetic analysis delineates a spectrum of chromosomal changes that can distinguish non-MALT marginal zone B-cell lymphomas among mature B-cell entities: a description of 103 cases
2005
Overview
The purpose of this study was to document the frequency and distribution of karyotypic changes present at diagnosis in 103 non-MALT marginal zone cell lymphoma (MZL) patients. This cytogenetic analysis of a large cohort extends previous observations and allows the identification of new cytogenetic features. Abnormalities identified in more than 15% of patients included +3/+3q (37%), 7q deletions (31%), +18/+18q (28%), 6q deletions (19%), +12/+12q (15%) and 8p deletions (15%). Trisomy 3/3q, 7q deletions, +18 and +12 were seen in different combinations in more than 30% of patients in comparison to 2% in lymphocytic lymphomas/chronic lymphocytic leukemias, 1% in mantle cell lymphomas and 7% in follicular lymphomas. The marked propensity of these abnormalities to be recurrently associated with the same tumoral clone of individual karyotypes allowed the delineation of a cytogenetic profile that may help to distinguish non-MALT MZL among other mature B-cell neoplasms. If +3/3q, +12/+12q, and 6q, 7q and 8p deletions were significantly associated with clinical prognostic factors previously reported to influence survival and time to progression, patients displaying these abnormalities did not experience a significantly shorter time to progression.
Publisher
Nature Publishing,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Biological and medical sciences
/ Female
/ Hematologic and hematopoietic diseases
/ Humans
/ In Situ Hybridization, Fluorescence
/ Leukemia
/ Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
/ Leukemia, Lymphocytic, Chronic, B-Cell - genetics
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Lymphoma
/ Lymphoma, B-Cell - classification
/ Lymphoma, B-Cell - diagnosis
/ Lymphoma, B-Cell, Marginal Zone - classification
/ Lymphoma, B-Cell, Marginal Zone - diagnosis
/ Lymphoma, B-Cell, Marginal Zone - genetics
/ Lymphoma, Follicular - diagnosis
/ Lymphoma, Follicular - genetics
/ Lymphoma, Mantle-Cell - diagnosis
/ Lymphoma, Mantle-Cell - genetics
/ Male
/ Mucosal-associated lymphoid tissue
/ Patients
/ Trisomy
