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Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia

by Kateh, Francis , Bolay, Fatorma , Logue, James , Wolfson, Julian , Follmann, Dean , Ballou, Ripley , Stavale, Eric , Lane, H. Clifford , Higgs, Elizabeth , Marchand, Jonathan , Eckes, Risa , Janosko, Krisztina , Monath, Thomas , Gupta, Swati , Grund, Birgit , Feinberg, Mark , Nason, Martha , Johnson, Melvin , Roman, François , Neaton, James D , Hensley, Lisa , Kieh, Mark , Badio, Moses , Kennedy, Stephen B , Grandits, Greg , Nyenswah, Tolbert

in Adenoviridae / Adenoviruses / Adult / Allergies / Animals / Antibody response / Clinical trials / Disease Outbreaks / Disease prevention / Double-Blind Method / Ebola Vaccines - adverse effects / Ebola Vaccines - immunology / Ebola virus / Ebolavirus / Ebolavirus - immunology / Epidemics / Fatigue / Female / Fever - etiology / Glycoproteins / Headache / Headache - etiology / Hemorrhagic Fever, Ebola - complications / Hemorrhagic Fever, Ebola - immunology / Hemorrhagic Fever, Ebola - prevention & control / HIV Seropositivity - complications / Humans / Immune response / Immunogenicity / Infectious diseases / Injection / Injections, Intramuscular - adverse effects / Liberia / Male / Myalgia - etiology / Outbreaks / Pain / Pan troglodytes / Reverse Transcriptase Polymerase Chain Reaction / RNA, Viral - blood / Stomatitis / Vaccines / Vesiculovirus

2017

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2017

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2017

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Journal Article

Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia

Kateh, Francis,

Bolay, Fatorma,

Logue, James,

Wolfson, Julian,

Follmann, Dean,

Ballou, Ripley,

Stavale, Eric,

Lane, H. Clifford,

Higgs, Elizabeth,

Marchand, Jonathan,

Eckes, Risa,

Janosko, Krisztina,

Monath, Thomas,

Gupta, Swati,

Grund, Birgit,

Feinberg, Mark,

Nason, Martha,

Johnson, Melvin,

Roman, François,

Neaton, James D,

Hensley, Lisa,

Kieh, Mark,

Badio, Moses,

Kennedy, Stephen B,

Grandits, Greg,

Nyenswah, Tolbert

2017

Overview

Ebola remains a global threat. In a randomized, controlled trial to assess the safety and immunogenicity of two vaccines against Ebola virus disease in Liberia, no safety signals were found. The vaccines elicited immune responses lasting at least 1 year.

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Publisher

Massachusetts Medical Society

Subject

/ Adult

/ Animals