Asset Details
Do you wish to reserve the book?
Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model
Do you wish to request the book?
Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model
2018
Overview
Magnetoliposomes (MLs) were synthesized and tested for longitudinal monitoring of transplanted pancreatic islets using magnetic resonance imaging (MRI) in rat models. The rat insulinoma cell line INS-1E and isolated pancreatic islets from outbred and inbred rats were used to optimize labeling conditions
in vitro
. Strong MRI contrast was generated by islets exposed to 50 µg Fe/ml for 24 hours without any increased cell death, loss of function or other signs of toxicity.
In vivo
experiments showed that pancreatic islets (50–1000 units) labeled with MLs were detectable for up to 6 weeks post-transplantation in the kidney subcapsular space. Islets were also monitored for two weeks following transplantation through the portal vein of the liver. Hereby, islets labeled with MLs and transplanted under the left kidney capsule were able to correct hyperglycemia and had stable MRI signals until nephrectomy. Interestingly,
in vivo
MRI of streptozotocin induced diabetic rats transplanted with allogeneic islets demonstrated loss of MRI contrast between 7–16 days, indicative of loss of islet structure. MLs used in this study were not only beneficial for monitoring the location of transplanted islets
in vivo
with high sensitivity but also reported on islet integrity and hereby indirectly on islet function and rejection.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/106
/ 14
/ 14/28
/ 38/77
/ 38/90
/ 59/57
/ Animals
/ Diabetes
/ Diabetes Mellitus, Experimental - chemically induced
/ Diabetes Mellitus, Experimental - metabolism
/ Diabetes Mellitus, Experimental - pathology
/ Humanities and Social Sciences
/ Islets of Langerhans - metabolism
/ Islets of Langerhans - pathology
/ Islets of Langerhans Transplantation - methods
/ Kidneys
/ Magnetic Resonance Imaging - methods
/ Magnetite Nanoparticles - administration & dosage
/ NMR
/ Pancreatic islet transplantation
/ Rats
/ Rodents
/ Science
/ Toxicity
