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Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice
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Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice
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Journal Article
Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice
2016
Overview
Th17 cells accrue in the intestine in response to particular microbes. In rodents, segmented filamentous bacteria (SFB) induce intestinal Th17 cells, but analogously functioning microbes in humans remain undefined. Here, we identified human symbiont bacterial species, in particular Bifidobacterium adolescentis, that could, alone, induce Th17 cells in the murine intestine. Similar to SFB, B. adolescentis was closely associated with the gut epithelium and engendered cognate Th17 cells without attendant inflammation. However, B. adolescentis elicited a transcriptional program clearly distinct from that of SFB, suggesting an alternative mechanism of promoting Th17 cell accumulation. Inoculation of mice with B. adolescentis exacerbated autoimmune arthritis in the K/BxN mouse model. Several off-the-shelf probiotic preparations that include Bifidobacterium strains also drove intestinal Th17 cell accumulation.
Publisher
National Academy of Sciences
Subject
/ Arthritis, Experimental - etiology
/ Arthritis, Experimental - immunology
/ Arthritis, Experimental - microbiology
/ Bacteria
/ Bifidobacterium adolescentis
/ Bifidobacterium adolescentis - immunology
/ Bifidobacterium adolescentis - isolation & purification
/ Cells
/ Female
/ Gastrointestinal Microbiome - immunology
/ Humans
/ Inflammatory Bowel Diseases - immunology
/ Inflammatory Bowel Diseases - microbiology
/ Inflammatory Bowel Diseases - pathology
/ Intestinal Mucosa - cytology
/ Intestinal Mucosa - immunology
/ Intestinal Mucosa - microbiology
/ Male
/ Mice
/ Rodents
