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A large family of Dscam genes with tandemly arrayed 5′ cassettes in Chelicerata
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Journal Article
A large family of Dscam genes with tandemly arrayed 5′ cassettes in Chelicerata
2016
Overview
Drosophila
Dscam1 (Down Syndrome Cell Adhesion Molecules) and vertebrate clustered protocadherins (Pcdhs) are two classic examples of the extraordinary isoform diversity from a single genomic locus.
Dscam1
encodes 38,016 distinct isoforms via mutually exclusive splicing in
D. melanogaster
, while the vertebrate clustered
Pcdh
s utilize alternative promoters to generate isoform diversity. Here we reveal a shortened
Dscam
gene family with tandemly arrayed 5′ cassettes in
Chelicerata
. These cassette repeats generally comprise two or four exons, corresponding to variable Immunoglobulin 7 (Ig7) or Ig7–8 domains of
Drosophila
Dscam1. Furthermore, extraordinary isoform diversity has been generated through a combination of alternating promoter and alternative splicing. These
sDscams
have a high sequence similarity with
Drosophila Dscam1
, and share striking organizational resemblance to the 5′ variable regions of vertebrate clustered
Pcdh
s. Hence, our findings have important implications for understanding the functional similarities between
Drosophila Dscam1
and vertebrate
Pcdh
s, and may provide further mechanistic insights into the regulation of isoform diversity.
Drosophila Dscam1
and vertebrate clustered protocadherins (
Pcdh
) are known for their extraordinary isoform diversity. Here authors identify a shortened
Dscam
gene family in
Chelicerata
, which displays homology to
Drosophila Dscam1
, and employs splicing patterns similar to that of vertebrate
Pcdhs
.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
