Asset Details
Do you wish to reserve the book?
Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections
Do you wish to request the book?
Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections
2019
Overview
Neutrophils are recruited to the airways of patients with acute respiratory distress syndrome (ARDS) where they acquire an activated pro-survival phenotype with an enhanced respiratory burst thought to contribute to ARDS pathophysiology. Our
in vitro
model enables blood neutrophil transepithelial migration into cell-free tracheal aspirate fluid from patients to recapitulate the primary airway neutrophil phenotype observed
in vivo
. Neutrophils transmigrated through our model toward airway fluid from children with lower respiratory viral infections coinfected with bacteria had elevated levels of neutrophil activation markers but paradoxically exhibited an inability to kill bacteria and a defective respiratory burst compared with children without bacterial coinfection. The airway fluid from children with bacterial coinfections had higher levels of neutrophil elastase activity, as well as myeloperoxidase levels compared to children without bacterial coinfection. Neutrophils transmigrated into the aspirate fluid from children with bacterial coinfection showed decreased respiratory burst and killing activity against
H
.
influenzae
and
S
.
aureus
compared to those transmigrated into the aspirate fluid from children without bacterial coinfection. Use of a novel transmigration model recapitulates this pathological phenotype
in vitro
that would otherwise be impossible in a patient, opening avenues for future mechanistic and therapeutic research.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/31
/ 14/1
/ 14/34
/ Bacteria
/ Bacterial Infections - immunology
/ Bacterial Infections - microbiology
/ Bacterial Infections - pathology
/ Bacterial Infections - virology
/ Child
/ Children
/ Elastase
/ Female
/ Haemophilus influenzae - immunology
/ Humanities and Social Sciences
/ Humans
/ Infant
/ Male
/ Respiratory Burst - immunology
/ Respiratory distress syndrome
/ Respiratory Distress Syndrome - immunology
/ Respiratory Distress Syndrome - microbiology
/ Respiratory Distress Syndrome - pathology
/ Respiratory Distress Syndrome - virology
/ Respiratory Tract Infections - immunology
/ Respiratory Tract Infections - microbiology
/ Respiratory Tract Infections - pathology
/ Respiratory Tract Infections - virology
/ Science
/ Staphylococcus aureus - immunology
