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Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule
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Journal Article
Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule
2018
Overview
Streptococcus pneumoniae’s
polysaccharide capsule is an important virulence factor; vaccine-induced immunity to specific capsular polysaccharide effectively prevents disease. Serotype 1
S
.
pneumoniae
is rarely found in healthy persons, but is highly invasive and a common cause of meningitis outbreaks and invasive disease outside of the United States. Here we show that genes for polysaccharide capsule similar to those expressed by pneumococci were commonly detected by polymerase chain reaction among upper respiratory tract samples from older US adults not carrying pneumococci. Serotype 1-specific genes were predominantly detected. In five oropharyngeal samples tested, serotype 1 gene belonging to
S
.
mitis
expressed capsules immunologically indistinct from pneumococcal capsules. Whole genome sequencing revealed three distinct
S
.
mitis
clones, each representing a
cps1
operon highly similar to the pneumococcal
cps1
reference operon. These findings raise important questions about the contribution of commensal streptococci to natural immunity against pneumococci, a leading cause of mortality worldwide.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45
/ 45/23
/ 45/77
/ 631/326
/ Bacterial Capsules - genetics
/ Bacterial Capsules - immunology
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Pneumococcal Infections - immunology
/ Pneumococcal Infections - microbiology
/ Pneumococcal Infections - prevention & control
/ Science
/ Streptococcus mitis - classification
/ Streptococcus mitis - genetics
/ Streptococcus pneumoniae - classification
/ Streptococcus pneumoniae - genetics
/ Vaccines
