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Brain white matter abnormalities in paediatric Gaucher Type I and Type III using diffusion tensor imaging
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Brain white matter abnormalities in paediatric Gaucher Type I and Type III using diffusion tensor imaging
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Journal Article
Brain white matter abnormalities in paediatric Gaucher Type I and Type III using diffusion tensor imaging
2011
Overview
Objective
Biomarkers to monitor neurological dysfunction in Neuronopathic Gaucher disease (NGD) are lacking. Diffusion tensor imaging (DTI) is a technique which allows us to probe the microstructure of the white-matter of the brain, in-vivo. The aim of this study was to investigate the value of DTI to visualise and quantify white matter integrity in children with NGD and Type I Gaucher.
Design
DTI was performed and fractional anisotropy (FA), mean diffusivity (MD), axial (λ
axial
) diffusivity and radial (λ
radial
) diffusivity maps calculated. Tract-based spatial statistics (TBSS) was used to perform a voxel-wise statistical analysis of the main white matter structures compared to age-sex matched control groups.
Setting
The study was performed at Great Ormond Street Children’s Hospital NHS Trust
Patients
Four NGD and three Type I Gaucher paediatric patients were recruited
Results
The findings suggest the presence of microstructural white matter changes in NGD patients primarily in the middle cerebellar peduncles compared to an age-sex matched control group. This finding is relevant to the clinical manifestation of ataxia seen in NGD. Diffuse non-specific changes were seen in the Type I patients, but without a focal point.
Conclusions
This study is the first to use DTI to examine the Gaucher brain. While the numbers studied are small, the results suggest that DTI may be an attractive surrogate marker of NGD, worthy of further exploration for use in clinical studies.
Publisher
Springer Netherlands,Springer,Blackwell Publishing Ltd
Subject
/ Biological and medical sciences
/ Brain
/ Child
/ Children
/ Diffusion Tensor Imaging - methods
/ Female
/ Gaucher Disease - metabolism
/ Genotype
/ Humans
/ Image Processing, Computer-Assisted
/ Images in Metabolic Medicine
/ Magnetic Resonance Imaging - methods
/ Male
/ Medicine
/ Probes
