Asset Details
Do you wish to reserve the book?
Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers
Do you wish to request the book?
Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers
2024
Overview
Background
Pancreatoduodenectomy is the only cure for cancers of the pancreas and the periampullary region but has considerable operative complications and uncertain prognosis. Our goal was to analyse temporal improvements and provide contemporary population-based benchmarks for outcomes following pancreatoduodenectomy.
Methods
We empanelled a cohort comprising all patients in Sweden with pancreatic or periampullary cancer treated with pancreatoduodenectomy from 1964 to 2016 and achieved complete follow-up through 2016. We analysed postoperative deaths and disease-specific net survival.
Results
We analysed 5923 patients with cancer of the pancreas (3876), duodenum (444), bile duct (504), or duodenal papilla (963) who underwent classic (3332) or modified (1652) Whipple’s procedure or total pancreatectomy (803). Postoperative deaths declined from 17.2% in the 1960s to 1.6% in the contemporary time period (2010–2016). For all four cancer types, median, 1-year and 5-year survival improved substantially over time. Among patients operated between 2010 and 2016, 5-year survival was 29.0% (95% confidence interval (CI): 25.5, 33.0) for pancreatic cancer, 71.2% (95% CI: 62.9, 80.5) for duodenal cancer, 30.8% (95% CI: 23.0, 41.3) for bile duct cancer, and 62.7% (95% CI: 55.5, 70.8) for duodenal papilla cancer.
Conclusion
There is a continuous and substantial improvement in the benefit-harm ratio after pancreatoduodenectomy for cancer.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Ampulla of Vater - pathology
/ Bile Duct Neoplasms - mortality
/ Bile Duct Neoplasms - surgery
/ Biomedical and Life Sciences
/ Cancer
/ Common Bile Duct Neoplasms - mortality
/ Common Bile Duct Neoplasms - pathology
/ Common Bile Duct Neoplasms - surgery
/ Duodenal Neoplasms - mortality
/ Duodenal Neoplasms - pathology
/ Duodenal Neoplasms - surgery
/ Duodenum
/ Female
/ Humans
/ Male
/ Oncology
/ Pancreatic Neoplasms - mortality
/ Pancreatic Neoplasms - surgery
/ Pancreaticoduodenectomy - methods
/ Pancreaticoduodenectomy - mortality
/ Survival
