Journal Article

Accuracy of MR neurography as a diagnostic tool in detecting injuries to the lingual and inferior alveolar nerve in patients with iatrogenic post-traumatic trigeminal neuropathy

Ahmadzai, Iraj, Jacobs, Reinhilde, Bangia, Mado, Politis, Constantinus, Van der Cruyssen, Fréderic, Casselman, Jan

2024

Overview

Objectives MR neurography has the ability to detect and depict peripheral nerve injuries. This study evaluated the potential of MR neurography in the diagnosis of post-traumatic trigeminal neuropathy. Methods Forty-one participants prospectively underwent MR neurography of the lingual and inferior alveolar nerves using a 3D TSE STIR black-blood sequence. Two blinded and independent observers recorded the following information for each nerve of interest: presence of injury, nerve thickness, nerve signal intensity, MR neurography Sunderland class, and signal gap. Afterwards, the apparent nerve-muscle contrast-to-noise ratio and apparent signal-to-noise ratio were calculated. Clinical data (neurosensory testing score and clinical Sunderland class) was extracted retrospectively from the medical records of patients diagnosed with post-traumatic trigeminal neuropathy. Results Compared to neurosensory testing, MR neurography had a sensitivity of 38.2% and specificity of 93.5% detecting nerve injuries. When differentiated according to clinical Sunderland class, sensitivity was 19.1% in the presence of a low class injury (I to III) and improved to 83.3% in the presence of a high class (IV to V). Specificity remained unchanged. The area under the curve using the apparent nerve-muscle contrast-to-noise ratio, apparent signal-to-noise ratio, and nerve thickness to predict the presence of an injury was 0.78 ( p  < .05). Signal intensities and nerve diameter increased in injured nerves ( p  < .05). Clinical and MR neurography Sunderland scores positively correlated (correlation coefficient = 0.53; p  = .005). Conclusions This study shows that MR neurography can accurately differentiate between injured and healthy nerves, especially in the presence of a more severe nerve injury. Clinical relevance statement MR neurography is not only able to detect trigeminal nerve injuries, but it can also provide information about the anatomical specifications of the injury, which is not possible with clinical neurosensory testing. This makes MR neurography an added value in the management of post-traumatic trigeminal neuropathy. Key Points • The current diagnosis of post-traumatic trigeminal neuropathy is mainly based on clinical examination. • MR neurography is able to visualize and stratify peripheral trigeminal nerve injuries. • MR neurography contributes to the diagnostic process as well as to further decision-making.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adult / Aged / Alveoli / Correlation coefficient / Correlation coefficients / Decision making / Diagnosis / Diagnostic Radiology / Female / Head and Neck / Humans / Iatrogenic Disease / Imaging / Injuries / Internal Medicine / Interventional Radiology / Lingual Nerve Injuries - diagnostic imaging / Magnetic Resonance Imaging - methods / Male / Mandibular Nerve - diagnostic imaging / Mandibular Nerve Injuries - diagnostic imaging / Mandibular Nerve Injuries - etiology / Medical diagnosis / Medical records / Medicine / Medicine & Public Health / Middle Aged / Muscles / Neuropathy / Neuroradiology / Noise prediction / Patients / Peripheral nerves / Peripheral neuropathy / Prospective Studies / Radiology / Sensitivity / Sensitivity analysis / Sensitivity and Specificity / Signal to noise ratio / Thickness / Transmissible spongiform encephalopathy / Trigeminal nerve / Trigeminal Nerve Diseases - diagnostic imaging / Trigeminal Nerve Diseases - etiology / Trigeminal Nerve Injuries - diagnostic imaging / Ultrasound / Young Adult