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Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

by Milazzo, Giorgio , Mercatelli, Daniele , Perini, Giovanni , Di Muzio, Giulia , Giorgi, Federico M. , Triboli, Luca , De Rosa, Piergiuseppe

in antineoplastic agents / Antineoplastic Agents - therapeutic use / Arthropods / Cell cycle / Chelonia mydas / chromatin / Chromatin remodeling / Enzymes / Eukaryotes / Evolutionary conservation / Gene expression / Genomes / HDAC protein / Histone deacetylase / Histone Deacetylase Inhibitors - therapeutic use / Histone Deacetylases - genetics / Histones / Histones - genetics / Humans / Insects / Mammals / moieties / Nematodes / Neoplasms - genetics / Neoplasms - therapy / Organisms / Pathogenesis / Phylogenetics / Proteins / Reptiles & amphibians / Review / Substrate Specificity - genetics / tissues / Transcription / transcription (genetics) / Transcription Factors - genetics / Yeast / Zebrafish

2020

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Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

by Milazzo, Giorgio , Mercatelli, Daniele , Perini, Giovanni , Di Muzio, Giulia , Giorgi, Federico M. , Triboli, Luca , De Rosa, Piergiuseppe

2020

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Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

by Milazzo, Giorgio , Mercatelli, Daniele , Perini, Giovanni , Di Muzio, Giulia , Giorgi, Federico M. , Triboli, Luca , De Rosa, Piergiuseppe

2020

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Journal Article

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Milazzo, Giorgio,

Mercatelli, Daniele,

Perini, Giovanni,

Di Muzio, Giulia,

Giorgi, Federico M.,

Triboli, Luca,

De Rosa, Piergiuseppe

2020

Overview

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes.

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Publisher

MDPI AG,MDPI

Subject

antineoplastic agents

/ Antineoplastic Agents - therapeutic use

/ Chromatin remodeling