Asset Details
Do you wish to reserve the book?
Identifying cognitive test scores associated with early tau burden in Alzheimer's disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Identifying cognitive test scores associated with early tau burden in Alzheimer's disease
Do you wish to request the book?
Identifying cognitive test scores associated with early tau burden in Alzheimer's disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Identifying cognitive test scores associated with early tau burden in Alzheimer's disease
2025
Overview
INTRODUCTION This study aimed to identify cognitive tests that optimally relate to tau positron emission tomography (PET) signal in the inferior temporal cortex (ITC), a neocortical region associated with early tau accumulation in Alzheimer's disease (AD). METHODS We analyzed cross‐sectional data from the harvard aging brain study (HABS) (n = 128) and the Anti‐Amyloid Treatment in Asymptomatic Alzheimer's (A4) study (n = 393). We used elastic net regression to identify the most robust cognitive correlates of tau PET signal in the ITC. Secondary analyses examined whether the cognitive correlates remained significantly associated with tau after adjusting for structural brain measures. RESULTS Episodic memory measures, including both total and “process” scores, were the most robust correlates of ITC tau across both cohorts. These cognitive test scores remained significant after accounting for structural brain measures. DISCUSSION These findings highlight the potential of specific episodic memory test scores to detect and monitor neuropathological changes associated with early AD. Highlights Machine learning identified cognitive correlates of early Alzheimer's disease tau burden. Both traditional and process scores predicted early tau burden. Episodic memory scores were among the strongest correlates. Cognitive scores remained significant after accounting for structural brain measures.
