Journal Article

Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

Marino, Claudia, Simone, Barbara, Cortegiani, Andrea, Catalisano, Giulia, Misseri, Giovanni, Filisina, Carlotta, Giarratano, Antonino, Catalanotto, Francesca Romana, Ippolito, Mariachiara

2021

Overview

Background: Little is known about the occurrence of bloodstream infections in hospitalized patients with COVID-19 and the related clinical consequences. The aim of this systematic review and meta-analysis was to estimate the pooled occurrence of BSIs among hospitalized patients with COVID-19 and mortality of this patient population. Methods: A systematic search was performed on PubMed, EMBASE, and Web of Science from inception to 19 April 2021. The primary outcome was the occurrence of BSIs among hospitalized patients with COVID-19. The secondary outcome was mortality at the longest available follow-up. Results: Forty-six studies met the inclusion criteria, with a total of 42,694 patients evaluated. The estimated occurrence of BSIs was 7.3% (95% CI 4.7–1.1%) among hospitalized patients with COVID-19, with a mortality rate of 41% (95% CI 30%–52.8%). The subgroup analysis conducted on patients admitted to ICU provided an estimated occurrence of 29.6% (95% CI 21.7%–38.8%). A higher occurrence of BSI was observed in patients with COVID-19, in comparison with patients without COVID-19 (OR 2.77; 95% CI 1.53–5.02; p < 0.001). Conclusions: Our analysis estimated the occurrence of BSIs among hospitalized patients with COVID-19 at around 7%. A four-times higher occurrence was estimated among patients admitted to ICU.

• Publisher: MDPI AG,MDPI
• Subject: blood flow / bloodstream infections / Coronaviruses / COVID-19 / COVID-19 infection / Hospitalization / Infections / Intensive care / Meta-analysis / Mortality / Pandemics / Patients / Pneumonia / review / Sensitivity analysis / Sepsis / Severe acute respiratory syndrome coronavirus 2 / Statistical analysis / Subgroups / Systematic review