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Influenza Viruses Resistant to the Antiviral Drug Oseltamivir: Transmission Studies in Ferrets
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Influenza Viruses Resistant to the Antiviral Drug Oseltamivir: Transmission Studies in Ferrets
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Journal Article
Influenza Viruses Resistant to the Antiviral Drug Oseltamivir: Transmission Studies in Ferrets
2004
Overview
Three type A influenza viruses, each of which has a distinct neuraminidase-gene mutation and is resistant to the neuraminidase inhibitor oseltamivir, have been isolated. Previously, in the ferret model, an R292K mutant of a type A (H3N2) virus was not transmitted under conditions in which the wild-type virus was transmitted. This model was used to investigate whether the E119V mutant of a type A (H3N2) virus and the H274Y mutant of a type A (H1N1) virus would be transmitted under similar circumstances. Both mutant viruses were transmitted, although the H274Y mutant required a 100-fold-higher dose for infection of donor ferrets and was transmitted more slowly than was the wild type. Both the mutant and the wild-type viruses retained their genotypic characteristics.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Animals
/ Antiviral Agents - pharmacology
/ Biological and medical sciences
/ Dosage
/ Ferrets
/ Fundamental and applied biological sciences. Psychology
/ H3N2 subtype influenza A virus
/ Influenza A virus - drug effects
/ Influenza A virus - genetics
/ Influenza A virus - growth & development
/ Mutation
/ Neuraminidase - antagonists & inhibitors
/ Orthomyxoviridae Infections - transmission
/ Orthomyxoviridae Infections - virology
/ Viruses
