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HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia
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HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia
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Journal Article
HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia
2011
Overview
Infection with human papillomavirus (HPV) serotypes 16 and 18 in men who have sex with men is a cause of considerable morbidity associated with anal intraepithelial neoplasia. This study shows that the HPV vaccine decreases the risk of HPV-associated anal disease.
Anal cancer is biologically similar to cervical cancer, including having a causal relationship with human papillomavirus (HPV) infection.
1
Although HPV type 6 (HPV-6) or HPV type 11 (HPV-11) alone is rarely causal, the proportion of anal cancers associated with infection with HPV type 16 (HPV-16) or HPV type 18 (HPV-18) is as high as or higher than the proportion of cervical cancers.
1
Just as cervical cancer is preceded by high-grade cervical intraepithelial neoplasia (grade ≥2), anal cancer is preceded by high-grade anal intraepithelial neoplasia (grade 2 or 3).
2
–
4
Although not yet formally demonstrated, prevention or treatment of high-grade anal . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Anus
/ Anus Diseases - prevention & control
/ Anus Neoplasms - prevention & control
/ Biological and medical sciences
/ Cancer
/ Carcinoma in Situ - prevention & control
/ Carcinoma in Situ - virology
/ Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
/ Humans
/ Male
/ Men
/ Papillomavirus Infections - prevention & control
/ Public health. Hygiene-occupational medicine
/ Sex
/ Vaccines
