Journal Article

Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

Roseman, Leor, Deco, Gustavo, Atasoy, Selen, Kaelen, Mendel, Kringelbach, Morten L., Carhart-Harris, Robin L.

2017

Overview

Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used ’connectome-harmonic decomposition’, a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Research
• Subject: 59/36 / 631/378 / 631/378/116/2393 / 631/378/2649/1398 / 692/53 / Adult / Biomarkers / Brain / Brain - physiology / Brain architecture / Connectome / Consciousness / Decomposition / Dynamical systems / Energy Metabolism / Female / Frequency distribution / Hallucinogens - metabolism / Healthy Volunteers / Humanities and Social Sciences / Humans / LSD / Lysergic acid diethylamide / Lysergic Acid Diethylamide - metabolism / Lysergide / Magnetic Resonance Imaging / Male / Models, Theoretical / multidisciplinary / Music / Nervous System Physiological Phenomena / Neuroscience / Science / Science (multidisciplinary) / Young Adult