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Optimizing Deep Learning Models for Luminal and Nonluminal Breast Cancer Classification Using Multidimensional ROI in DCE‐MRI—A Multicenter Study
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Optimizing Deep Learning Models for Luminal and Nonluminal Breast Cancer Classification Using Multidimensional ROI in DCE‐MRI—A Multicenter Study
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Optimizing Deep Learning Models for Luminal and Nonluminal Breast Cancer Classification Using Multidimensional ROI in DCE‐MRI—A Multicenter Study
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Journal Article
Optimizing Deep Learning Models for Luminal and Nonluminal Breast Cancer Classification Using Multidimensional ROI in DCE‐MRI—A Multicenter Study
2025
Overview
Objectives Previous deep learning studies have not explored the synergistic effects of ROI dimensions (2D/2.5D/3D), peritumoral expansion levels (0–8 mm), and segmentation scenarios (ROI only vs. ROI original). Our study aims to evaluate the performance of multidimensional deep transfer learning models in distinguishing molecular subtypes of breast cancer (luminal vs. nonluminal) using DCE‐MRI. Under two segmentation scenarios, we systematically compare the effects of ROI dimensions and peritumoral expansion levels to optimize multidimensional deep learning models via transfer learning for distinguishing luminal from nonluminal breast cancers in DCE‐MRI‐based analysis. Materials and Methods From October 2020 to October 2023, data from 426 patients with primary invasive breast cancer were retrospectively collected. Patients were divided into three cohorts: (1) training cohort, n = 108, from SYSU Hospital (Zhuhai, China); (2) validation cohort 1, n = 165, from HZ Hospital (Huizhou, China); and (3) validation cohort 2, n = 153, from LY Hospital (Linyi, China). ROIs were delineated, and expansions of 2, 4, 6, and 8 mm beyond the lesion boundary were performed. We assessed the performance of various deep transfer learning models, considering precise segmentation (ROI only and ROI original) and varying peritumoral regions, using ROC curves and decision curve analysis. Results The 2.5D1‐based deep learning model (ROI original, 4 mm expansion) demonstrated optimal performance, achieving an AUC of 0.808 (95% CI 0.715–0.901) in the training cohort, 0.766 (95% CI 0.682–0.850) in validation cohort 1, and 0.799 (95% CI 0.725–0.874) in validation cohort 2. Conclusion The study highlights that the 2.5D1‐based deep learning model utilizing the three principal slices of the minimum bounding box (ROI original) with a 4 mm peritumoral region is effective in distinguishing between luminal and nonluminal breast cancer tumors, serving as a potential diagnostic tool.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
