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Analysis of Aedes aegypti microRNAs in response to Wolbachia wAlbB infection and their potential role in mosquito longevity
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Analysis of Aedes aegypti microRNAs in response to Wolbachia wAlbB infection and their potential role in mosquito longevity
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Journal Article
Analysis of Aedes aegypti microRNAs in response to Wolbachia wAlbB infection and their potential role in mosquito longevity
2022
Overview
The mosquito
Aedes aegypti
is the primary vector of a range of medically important viruses including dengue, Zika, West Nile, yellow fever, and chikungunya viruses. The endosymbiotic bacterium
Wolbachia pipientis w
AlbB strain is a promising biocontrol agent for blocking viral transmission by
Ae. aegypti
. To predict the long-term efficacy of field applications, a thorough understanding of the interactions between symbiont, host, and pathogen is required.
Wolbachia
influences host physiology in a variety of ways including reproduction, immunity, metabolism, and longevity. MicroRNAs (miRNAs) are highly conserved small non-coding RNAs that regulate gene expression in eukaryotes and viruses. Several miRNAs are known to regulate biological processes in
Drosophila
and mosquitoes, including facilitating
Wolbachia
maintenance. We generated the first chromosomal map of
Ae. aegypti
miRNAs, and compared miRNA expression profiles between a
w
AlbB-transinfected
Ae. aegypti
mosquito line and a tetracycline cleared derivative, using deep small RNA-sequencing. We found limited modulation of miRNAs in response to
w
AlbB infection. Several miRNAs were modulated in response to age, some of which showed greater upregulation in
w
AlbB-infected mosquitoes than in tetracycline cleared ones. By selectively inhibiting some differentially expressed miRNAs, we identified miR-2946-3p and miR-317-3p as effecting mosquito longevity in
Wolbachia
-infected mosquitoes.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
