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A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2
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A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2
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Journal Article
A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2
2019
Overview
Continuous low-level supply or in situ generation of hydrogen peroxide (H
2
O
2
) is essential for the stability of unspecific peroxygenases, which are deemed ideal biocatalysts for the selective activation of C–H bonds. To envisage potential large scale applications of combined catalytic systems the reactions need to be simple, efficient and produce minimal by-products. We show that gold-palladium nanoparticles supported on TiO
2
or carbon have sufficient activity at ambient temperature and pressure to generate H
2
O
2
from H
2
and O
2
and supply the oxidant to the engineered unspecific heme-thiolate peroxygenase PaDa-I. This tandem catalyst combination facilitates efficient oxidation of a range of C-H bonds to hydroxylated products in one reaction vessel with only water as a by-product under conditions that could be easily scaled.
Continuous low-level supply or in situ generation of hydrogen peroxide (H
2
O
2
) is essential for the stability of unspecific peroxygenases. Here, the authors demonstrate that AuPd / TiO
2
can generate sufficient H
2
O
2
for the engineered unspecific heme-thiolate peroxygenase PaDa-I to oxidise a range of C-H bonds.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
