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Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Limits the Expansion of Encephalitogenic T Cells in Experimental Autoimmune Encephalomyelitis (EAE)-Resistant BALB/c Mice
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Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Limits the Expansion of Encephalitogenic T Cells in Experimental Autoimmune Encephalomyelitis (EAE)-Resistant BALB/c Mice
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Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Limits the Expansion of Encephalitogenic T Cells in Experimental Autoimmune Encephalomyelitis (EAE)-Resistant BALB/c Mice
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Journal Article
Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Limits the Expansion of Encephalitogenic T Cells in Experimental Autoimmune Encephalomyelitis (EAE)-Resistant BALB/c Mice
2002
Overview
We and others previously reported that cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the severity of peptide-induced experimental autoimmune encephalomyelitis (EAE) in mouse strains that are inherently susceptible to the disease. In this report, we show that CTLA-4 engagement also controls disease susceptibility in BALB/c mice, a strain considered to be resistant to EAE induction. Although immunization of BALB/c mice with syngeneic spinal cord homogenate or an I-Ad-binding myelin peptide antigen failed to result in EAE, immunization with either antigen preparation in conjunction with anti-CTLA-4 resulted in both clinical and histological EAE. CTLA-4 blockade also resulted in a preferential increase in the frequency of antigen-specific T cells secreting IFN-γ. We conclude that CTLA-4 controls susceptibility in BALB/c mice by limiting the expansion of autoreactive T cells present in the periphery, suggesting a mechanism whereby CTLA-4 contributes to the maintenance of peripheral T cell tolerance to self antigens.
Publisher
National Academy of Sciences,National Acad Sciences,The National Academy of Sciences
Subject
/ Animals
/ Antigens
/ Antigens, Differentiation - immunology
/ Cells
/ Encephalomyelitis, Autoimmune, Experimental - immunology
/ Female
/ Immunity, Innate - immunology
/ Interferon-gamma - secretion
/ Mice
/ Myelin
/ Myelin Proteolipid Protein - immunology
/ Myelin Proteolipid Protein - pharmacology
/ Peptide Fragments - pharmacology
/ Rodents
