Asset Details
Do you wish to reserve the book?
Reactivation of Human Herpesvirus Type 6 in Multiple Organ Failure Syndrome
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Reactivation of Human Herpesvirus Type 6 in Multiple Organ Failure Syndrome
Do you wish to request the book?
Reactivation of Human Herpesvirus Type 6 in Multiple Organ Failure Syndrome
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Reactivation of Human Herpesvirus Type 6 in Multiple Organ Failure Syndrome
2001
Overview
Human herpesvirus type 6 (HHV-6) and cytomegalovirus (CMV) are known to interact with the production of cytokines. In this study, we sought to determine the incidence of HHV-6 and CMV reactivation during multiple organ failure syndrome (MOFS) and to evaluate the potential effects of viral replication on both the morbidity and mortality associated with MOFS. Viral reactivation was assessed by use of specific polymerase chain reaction (PCR) analysis of the serum samples obtained from 48 consecutive patients with MOFS (the MOFS group) and from 48 sex- and age-matched patients with <2 organ failures (the control group). In addition, HHV-6 replication was assessed in 106 blood donors (the normal group). The incidence of HHV-6 replication was higher in the MOFS group than in the control and normal groups (26 [54%] of 48 vs. 7 [15%] of 48 and 5 [5%] of 106, respectively; P < .0001), with apparently no influence on morbidity and mortality rates. In contrast, reactivation of CMV was found in a single patient. Further studies are needed to evaluate the pathogenesis of HHV-6 replication in critically ill patients.
Publisher
The University of Chicago Press,University of Chicago Press
Subject
/ Adult
/ Aged
/ Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
/ Biological and medical sciences
/ Cytomegalovirus Infections - blood
/ Cytomegalovirus Infections - virology
/ Female
/ Herpesviridae Infections - blood
/ Herpesviridae Infections - virology
/ Herpesvirus 6, Human - growth & development
/ Herpesvirus 6, Human - isolation & purification
/ Humans
/ Male
/ Multiple Organ Failure - blood
/ Multiple Organ Failure - mortality
/ Multiple Organ Failure - virology
/ multiple organ failure syndrome
/ Sofas
