Journal Article

Perimyocarditis following first dose of the mRNA-1273 SARS-CoV-2 (Moderna) vaccine in a healthy young male: a case report

Xie, Min, Aziz, Muhammad U., Hasnie, Usman A., Hasnie, Ammar A., Patel, Nirav, Prabhu, Sumanth D., Lloyd, Steven G.

2021

Overview

Background Half of U.S. adults have received at least one dose of the COVID-19 vaccines produced by either Pfizer, Moderna, or Johnson and Johnson, which represents a major milestone in the ongoing pandemic. Given the emergency use authorizations for these vaccines, their side effects and safety were assessed over a compressed time period. Hence, ongoing monitoring for vaccine-related adverse events is imperative for a full understanding and delineation of their safety profile. Case presentation An 22-year-old Caucasian male presented to our hospital center complaining of pleuritic chest pain. Six months prior he had a mild case of COVID-19, but was otherwise healthy. He had received his first dose of the Moderna vaccine three days prior to developing symptoms. Laboratory analysis revealed a markedly elevated troponin and multiple imaging modalities during his hospitalization found evidence of wall motion abnormalities consistent with a diagnosis of perimyocarditis. He was started on aspirin and colchicine with marked improvement of his symptoms prior to discharge. Conclusions We present a case of perimyocarditis that was temporally related to COVID-19 mRNA vaccination in an young male with prior COVID-19 infection but otherwise healthy. Our case report highlights an albeit rare but important adverse event for clinicians to be aware of. It also suggests a possible mechanism for the development of myocardial injury in our patient.

• Publisher: BioMed Central,Springer Nature B.V,BMC
• Subject: Adverse events / Angiology / Antigens / Aspirin / Blood Transfusion Medicine / Calcium-binding protein / Cardiac MRI / Cardiac Surgery / Cardiology / Case Report / Colchicine / Coronaviruses / COVID-19 / COVID-19 vaccines / Cytotoxicity / Disease / Drug dosages / ECG / Electrocardiography / Heart rate / Infections / Inflammation / Internal Medicine / Lymphocytes / Medicine / Medicine & Public Health / mRNA / mRNA vaccines / Myocarditis / Myopericarditis / Pain / Pandemics / Patients / Primary Prevention and Cardiovascular Risk / Proteins / Severe acute respiratory syndrome coronavirus 2 / Troponin / Vaccines / Viral infections