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Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension
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Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension
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Journal Article
Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension
2013
Overview
In this trial, 261 patients with chronic thromboembolic pulmonary hypertension were assigned to placebo or to the soluble guanylate cyclase stimulator riociguat. At 16 weeks, riociguat had significantly improved the 6-minute walk distance and pulmonary vascular resistance.
Chronic thromboembolic pulmonary hypertension is characterized by obstruction of the pulmonary vasculature by residual organized thrombi,
1
leading to increased pulmonary vascular resistance, progressive pulmonary hypertension, and right ventricular failure.
2
,
3
Patients with chronic thromboembolic pulmonary hypertension have a poor prognosis unless they receive treatment early.
4
Pulmonary endarterectomy is the standard treatment for chronic thromboembolic pulmonary hypertension and is the only potentially curative treatment.
5
However, surgery is not an option for all patients; some patients are ineligible for surgery owing to the occlusion of distal vessels or coexisting conditions, some decline surgery, and some do not have access to expert surgical . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Chest
/ Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
/ Dyspnea
/ Exercise Tolerance - drug effects
/ Female
/ Heart
/ Humans
/ Hypertension, Pulmonary - drug therapy
/ Hypertension, Pulmonary - physiopathology
/ Male
/ Patients
/ Pulmonary Embolism - complications
/ Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
/ Pyrimidines - adverse effects
/ Pyrimidines - therapeutic use
/ Surgery
/ Syncope
/ Vascular Resistance - drug effects
/ Walking
