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A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus
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A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus
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Journal Article
A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus
2014
Overview
Congenital infection with cytomegalovirus is a major cause of morbidity in neonates. In this phase 2, placebo-controlled trial, hyperimmune globulin given to mothers with primary CMV infection at 5 to 26 weeks of gestation did not significantly alter the course of infection.
Every year, approximately 0.6% of all newborns in the United States and the European Union are congenitally infected with human cytomegalovirus (CMV).
1
,
2
Approximately 20% of these infected newborns are symptomatic at birth or will have sequelae such as sensorineural hearing loss, cognitive defects, and motor defects.
3
Primary CMV infection that develops in a woman during pregnancy confers the highest risk of congenital infection and disease.
4
Identification of pregnant women with primary CMV infection is feasible by means of detection of virus-specific IgM and low IgG avidity. However, the unavailability of a therapeutic intervention of proven efficacy in the case . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Birth
/ Cytomegalovirus - immunology
/ Cytomegalovirus Infections - congenital
/ Cytomegalovirus Infections - prevention & control
/ Cytomegalovirus Infections - therapy
/ DNA
/ Female
/ Fetal Diseases - prevention & control
/ Fetuses
/ Humans
/ Immunoglobulins - administration & dosage
/ Infants
/ Infectious Disease Transmission, Vertical - prevention & control
/ Infectious Disease Transmission, Vertical - statistics & numerical data
/ Mothers
