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Two-Year Outcomes after Transcatheter or Surgical Aortic-Valve Replacement
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Two-Year Outcomes after Transcatheter or Surgical Aortic-Valve Replacement
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Journal Article
Two-Year Outcomes after Transcatheter or Surgical Aortic-Valve Replacement
2012
Overview
This study provides 2-year data from the PARTNER trial, in which patients with aortic stenosis received transcatheter aortic-valve replacement (TAVR) or surgical replacement. Overall mortality was similar, but paravalvular leak increased mortality in the TAVR group.
Aortic stenosis is associated with high mortality after the appearance of cardiac symptoms.
1
Nevertheless, many patients do not undergo surgical aortic-valve replacement owing to real or perceived increased risks associated with surgery.
2
–
5
Transcatheter aortic-valve replacement (TAVR) has emerged as an alternative therapy in high-risk patients with aortic stenosis.
6
–
10
Observational registries from various countries have reported 1-month and 1-year outcomes after TAVR,
11
–
14
but there are limited long-term follow-up data.
15
The Placement of Aortic Transcatheter Valves (PARTNER) trial was a randomized trial comparing TAVR with standard-of-care therapies in high-risk patients with aortic stenosis. One-year mortality outcomes from PARTNER showed . . .
Publisher
Massachusetts Medical Society
Subject
Anticoagulants - adverse effects
/ Anticoagulants - therapeutic use
/ Aortic Valve - diagnostic imaging
/ Aortic Valve Insufficiency - classification
/ Aortic Valve Insufficiency - etiology
/ Aortic Valve Stenosis - complications
/ Aortic Valve Stenosis - mortality
/ Aortic Valve Stenosis - surgery
/ Aortic Valve Stenosis - therapy
/ Biological and medical sciences
/ Cardiac Catheterization - adverse effects
/ Female
/ Heart Valve Prosthesis Implantation - adverse effects
/ Heart Valve Prosthesis Implantation - methods
/ Humans
/ Male
/ Platelet Aggregation Inhibitors - adverse effects
/ Platelet Aggregation Inhibitors - therapeutic use
/ Stenosis
/ Surgery
