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Prognostic Role of Inflammatory Biomarkers in Gastrointestinal Neuroendocrine Neoplasms: A Cross‐Sectional Study
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Prognostic Role of Inflammatory Biomarkers in Gastrointestinal Neuroendocrine Neoplasms: A Cross‐Sectional Study
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Journal Article
Prognostic Role of Inflammatory Biomarkers in Gastrointestinal Neuroendocrine Neoplasms: A Cross‐Sectional Study
2025
Overview
Background and Aims Gastrointestinal neuroendocrine neoplasms (g‐NENs) represent a heterogeneous group of tumors with variable prognoses. Inflammation‐based markers, such as the neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR), have emerged as potential prognostic indicators in various malignancies. This study aimed to evaluate the prognostic significance of NLR and PLR in g‐NENs and their associations with histopathological features and survival outcomes. Methods A retrospective, cross‐sectional study was conducted on 80 patients with histologically confirmed g‐NENs from April 2017 to March 2019. Baseline NLR and PLR were calculated, and their relationships with tumor grade, Ki‐67 proliferation index, metastatic status, and survival outcomes were analyzed. Cox regression and logistic regression models were used to determine independent prognostic factors. Results The hazard of death was approximately one‐third in the low NLR group after adjusting for metastasis and tumor grade (HR = 0.33, 95% CI: 0.14–0.80, p < 0.05). Elevated PLR was associated with poor outcomes; however, the difference between the high and low PLR groups was not statistically significant. Higher tumor grades and elevated Ki‐67 indices correlated with worse survival and increased metastatic potential (p < 0.001). No significant associations were observed for CRP or ESR levels with survival. Conclusion Our findings suggest that NLR may serve as an independent and accessible prognostic marker in g‐NENs, potentially offering a cost‐effective tool to support clinical decision‐making. The combined assessment of inflammatory biomarkers and histopathological parameters could improve prognostic accuracy and help guide personalized management strategies in patients with g‐NENs. Nevertheless, these observations should be interpreted with caution due to the retrospective, single‐center design and limited sample size. Future large‐scale, prospective studies are warranted to confirm and expand upon these results.
Publisher
John Wiley & Sons, Inc,Wiley
