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Two independent variants of epidermal growth factor receptor associated with risk of glioma in a Korean population
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Two independent variants of epidermal growth factor receptor associated with risk of glioma in a Korean population
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Journal Article
Two independent variants of epidermal growth factor receptor associated with risk of glioma in a Korean population
2022
Overview
Gliomas are the most common primary tumors in the brain and spinal cord. In previous GWASs, SNPs in
epidermal growth factor receptor
(
EGFR
) have been reported as risk loci for gliomas. However,
EGFR
variants associated with gliomas in the Korean population remain unstudied. This study explored the association of
EGFR
SNPs with the risk of glioma. We genotyped 13
EGFR
exon SNPs in a case–control study that included 324 Korean patients diagnosed with glioma and 480 population-based controls. Statistical analyses of the association between
EGFR
SNPs and glioma risk were conducted using logistic regression. Both stepwise analysis and conditional logistic analysis were performed to identify independent associations among genotyped variants. We confirmed that two SNPs (
rs2227983, rs1050171
) were significantly associated with glioma (
rs2227983
: odds ratio = 1.42,
P
corr
= 0.009;
rs1050171
: odds ratio = 1.68,
P
corr
= 0.005). Additionally, the stepwise analysis and conditional logistic analysis indicated that both SNPs created variants with independent genetic effects. This study is the first to show evidence that functional variants of
EGFR
, namely,
rs2227983
(K521R) and
rs1050171
(Q787Q), are associated with an increased risk of glioma in the Korean population. Future work should confirm the functional association between
EGFR
variants and glioma.
Publisher
Springer Science and Business Media LLC,Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
