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A Controlled Study of Inhaled Pentamidine for Primary Prevention of Pneumocystis carinii Pneumonia
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A Controlled Study of Inhaled Pentamidine for Primary Prevention of Pneumocystis carinii Pneumonia
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Journal Article
A Controlled Study of Inhaled Pentamidine for Primary Prevention of Pneumocystis carinii Pneumonia
1991
Overview
IN Western Europe and the United States, pneumonia due to
Pneumocystis
carinii (PCP) is the most important opportunistic infection in the acquired immunodeficiency syndrome (AIDS).
1
,
2
Therefore, its prevention would be a major step in controlling the consequences of human immunodeficiency virus (HIV) infection.
Co-trimoxazole and pentamidine are effective treatments for PCP.
3
However, without prevention, relapses occur in a majority of patients less than a year after a first episode.
4
Attempts at prevention have involved low doses of oral drugs, such as daily co-tri-moxazole,
5
,
6
dapsone,
7
or weekly pyrimethamine—sulfadoxine.
8
Oral administration has the disadvantage of systemic side effects,
9
which may interfere with . . .
Publisher
Massachusetts Medical Society
Subject
Acquired immune deficiency syndrome
/ Acquired Immunodeficiency Syndrome - complications
/ Adult
/ Aerosols
/ Aged
/ AIDS
/ AIDS-Related Complex - complications
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Biological and medical sciences
/ Female
/ HIV
/ HIV Seropositivity - complications
/ Human immunodeficiency virus
/ Humans
/ Male
/ Patients
/ Pentamidine - administration & dosage
/ Pentamidine - adverse effects
/ Pentamidine - therapeutic use
/ Pharmacology. Drug treatments
/ Pneumonia, Pneumocystis - prevention & control
/ Sodium
