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Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest

by Giraudeau, Bruno , Renon-Carron, Françoise , Quenot, Jean-Pierre , Clere-Jehl, Raphaël , Plantefève, Gaëtan , Bedon-Carte, Sandrine , Guitton, Christophe , Daix, Thomas , Deye, Nicolas , Durand-Zaleski, Isabelle , Kamel, Toufik , Dequin, Pierre-François , Legriel, Stéphane , Chudeau, Nicolas , Vignon, Philippe , Cariou, Alain , Diehl, Jean-Luc , François, Bruno , Karam, Elias , Le Gouge, Amélie , Desachy, Arnaud

in Adult / Aged / Amoxicillin / Amoxicillin-Potassium Clavulanate Combination - adverse effects / Amoxicillin-Potassium Clavulanate Combination - therapeutic use / Anesthesia / Anti-Bacterial Agents - adverse effects / Anti-Bacterial Agents - therapeutic use / Antibiotics / Bacteria / Cardiac arrest / Cardiopulmonary resuscitation / Clinical trials / Colonization / CPR / Disease management / Disease prevention / Double-Blind Method / Epidemiology / Female / Heart / Heart attacks / Hospitalization / Humans / Injections, Intravenous / Intensive Care Units / Intravenous administration / Length of Stay / Life Sciences / Male / Medical prognosis / Microbiota / Middle Aged / Mortality / Multidrug resistance / Multidrug resistant organisms / Nosocomial infections / Out-of-Hospital Cardiac Arrest - complications / Out-of-Hospital Cardiac Arrest - mortality / Patients / Penicillin / Pneumonia / Pneumonia, Ventilator-Associated - etiology / Pneumonia, Ventilator-Associated - microbiology / Pneumonia, Ventilator-Associated - prevention & control / Prevention / Staphylococcus infections / Treatment Outcome / Ventilator Weaning / Ventilator-associated pneumonia / Ventilators

2019

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Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest

2019

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Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest

2019

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Journal Article

Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest

Giraudeau, Bruno,

Renon-Carron, Françoise,

Quenot, Jean-Pierre,

Clere-Jehl, Raphaël,

Plantefève, Gaëtan,

Bedon-Carte, Sandrine,

Guitton, Christophe,

Daix, Thomas,

Deye, Nicolas,

Durand-Zaleski, Isabelle,

Kamel, Toufik,

Dequin, Pierre-François,

Legriel, Stéphane,

Chudeau, Nicolas,

Vignon, Philippe,

Cariou, Alain,

Diehl, Jean-Luc,

François, Bruno,

Karam, Elias,

Le Gouge, Amélie,

Desachy, Arnaud

2019

Overview

Patients treated with targeted temperature management (32 to 34°C) after cardiac arrest are at increased risk for early ventilator-associated pneumonia. In this multicenter trial, intravenous amoxicillin–clavulanate for 48 hours after cardiac arrest resulted in a lower incidence of early ventilator-associated pneumonia than placebo but did not affect ventilator-free days or mortality at day 28.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Aged

/ Amoxicillin

/ Amoxicillin-Potassium Clavulanate Combination - adverse effects

/ Amoxicillin-Potassium Clavulanate Combination - therapeutic use

/ Anesthesia

/ Anti-Bacterial Agents - adverse effects