Journal Article

Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015

Nikolaevskaya, Elena, Rzhepishevska, Olena, Molina-Moya, Barbara, Kohl, Thomas A., Stokich, Valentyna, Dominguez, Jose, Pavlovska, Olha, Marynova, Iryna, Dudnyk, Andrii, Barilar, Ivan, Niemann, Stefan, Merker, Matthias, Sjöstedt, Anders, Brännberg, Patrik, Filipova, Tetiana, Prat, Cristina

2020

Overview

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.

• Publisher: Centers for Disease Control and Prevention
• Subject: Adult / antimicrobial resistance / Antitubercular Agents - pharmacology / Antitubercular Agents - therapeutic use / Beijing Clades, Ukraine, 2015 / Beijing lineage / Contact Tracing / Drug resistance / Drug Resistance, Multiple, Bacterial - genetics / Epidemics / Extensively Drug-Resistant Tuberculosis - drug therapy / Extensively Drug-Resistant Tuberculosis - epidemiology / Extensively Drug-Resistant Tuberculosis - etiology / Female / Genomes / Humans / Male / MDR TB / Medical laboratories / Middle Aged / Multidrug- and Extensively Drug-Resistant / Mutation / Mycobacterium tuberculosis / Mycobacterium tuberculosis - drug effects / Mycobacterium tuberculosis - genetics / Outbreaks / Patients / Phylogenetics / Software / Tuberculosis / tuberculosis and other mycobacteria / Tuberculosis, Multidrug-Resistant - drug therapy / Tuberculosis, Multidrug-Resistant - epidemiology / Tuberculosis, Multidrug-Resistant - etiology / Tuberculosis, Pulmonary - drug therapy / Tuberculosis, Pulmonary - epidemiology / Tuberculosis, Pulmonary - etiology / Ukraine / Ukraine - epidemiology / Urban Population / Variance analysis / Whole genome sequencing / XDR TB