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Co-detection of Bordetella pertussis and other respiratory organisms in children hospitalised with lower respiratory tract infection
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Co-detection of Bordetella pertussis and other respiratory organisms in children hospitalised with lower respiratory tract infection
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Journal Article
Co-detection of Bordetella pertussis and other respiratory organisms in children hospitalised with lower respiratory tract infection
2020
Overview
Multiple potential pathogens are frequently co-detected among children with lower respiratory tract infection (LRTI). Evidence indicates that
Bordetella pertussis
has an important role in the aetiology of LRTI. We aimed to study the association between
B. pertussis
and other respiratory pathogens in children hospitalised with severe LRTI, and to assess clinical relevance of co-detection. Nasopharyngeal (NP) swabs and induced sputa (IS) were tested with a
B. pertussis
specific PCR; additionally, IS was tested for other pathogens using a multiplex PCR. We included 454 children, median age 8 months (IQR 4–18), 31 (7%) of whom tested positive for
B. pertussis
. Children with
B. pertussis
had more bacterial pathogens detected (3 versus 2; P < 0.001). While
B. pertussis
showed no association with most pathogens
,
it was independently associated with
Chlamydia pneumoniae, Mycoplasma pneumoniae
and parainfluenza viruses with adjusted risk ratios of 4.01 (1.03–15.64), 4.17 (1.42–12.27) and 2.13 (1.03–4.55), respectively. There was a consistent increased risk of severe disease with
B. pertussis.
Patterns indicated even higher risks when
B. pertussis
was co-detected with any of the three organisms although not statistically significant. Improving vaccine coverage against
B. pertussis
would impact not only the incidence of pertussis but also that of severe LRTI generally.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Bordetella pertussis - genetics
/ Bordetella pertussis - isolation & purification
/ Children
/ Chlamydophila pneumoniae - genetics
/ Chlamydophila pneumoniae - isolation & purification
/ Female
/ Humanities and Social Sciences
/ Humans
/ Infant
/ Male
/ Multiplex Polymerase Chain Reaction - methods
/ Mycoplasma pneumoniae - genetics
/ Mycoplasma pneumoniae - isolation & purification
/ Respiratory Tract Infections - microbiology
/ Respiratory Tract Infections - virology
/ Respirovirus - isolation & purification
/ Science
/ Sexually transmitted diseases
/ STD
