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Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
by
Berhane, Yohannes
, Xu, Wanhong
, Weese, J. Scott
, Lung, Oliver
, Ojkic, Davor
, Handel, Katherine
in
45/90
/ 45/91
/ 631/326/596/1578
/ 692/699/255/1578
/ Animals
/ China
/ Communicable Diseases, Imported - epidemiology
/ Communicable Diseases, Imported - veterinary
/ Communicable Diseases, Imported - virology
/ Complement component C3b
/ Disease Outbreaks - veterinary
/ Dog Diseases - epidemiology
/ Dog Diseases - transmission
/ Dog Diseases - virology
/ Dogs
/ Epidemiology
/ Genetic diversity
/ Humanities and Social Sciences
/ Influenza
/ Influenza A
/ Influenza A Virus, H3N2 Subtype - genetics
/ Influenza A Virus, H3N2 Subtype - isolation & purification
/ Molecular Epidemiology
/ multidisciplinary
/ Ontario - epidemiology
/ Orthomyxoviridae Infections - epidemiology
/ Orthomyxoviridae Infections - transmission
/ Orthomyxoviridae Infections - veterinary
/ Orthomyxoviridae Infections - virology
/ Outbreaks
/ Phylogenetics
/ Phylogeny
/ Republic of Korea
/ Science
/ Science (multidisciplinary)
2020
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Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
by
Berhane, Yohannes
, Xu, Wanhong
, Weese, J. Scott
, Lung, Oliver
, Ojkic, Davor
, Handel, Katherine
in
45/90
/ 45/91
/ 631/326/596/1578
/ 692/699/255/1578
/ Animals
/ China
/ Communicable Diseases, Imported - epidemiology
/ Communicable Diseases, Imported - veterinary
/ Communicable Diseases, Imported - virology
/ Complement component C3b
/ Disease Outbreaks - veterinary
/ Dog Diseases - epidemiology
/ Dog Diseases - transmission
/ Dog Diseases - virology
/ Dogs
/ Epidemiology
/ Genetic diversity
/ Humanities and Social Sciences
/ Influenza
/ Influenza A
/ Influenza A Virus, H3N2 Subtype - genetics
/ Influenza A Virus, H3N2 Subtype - isolation & purification
/ Molecular Epidemiology
/ multidisciplinary
/ Ontario - epidemiology
/ Orthomyxoviridae Infections - epidemiology
/ Orthomyxoviridae Infections - transmission
/ Orthomyxoviridae Infections - veterinary
/ Orthomyxoviridae Infections - virology
/ Outbreaks
/ Phylogenetics
/ Phylogeny
/ Republic of Korea
/ Science
/ Science (multidisciplinary)
2020
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Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
by
Berhane, Yohannes
, Xu, Wanhong
, Weese, J. Scott
, Lung, Oliver
, Ojkic, Davor
, Handel, Katherine
in
45/90
/ 45/91
/ 631/326/596/1578
/ 692/699/255/1578
/ Animals
/ China
/ Communicable Diseases, Imported - epidemiology
/ Communicable Diseases, Imported - veterinary
/ Communicable Diseases, Imported - virology
/ Complement component C3b
/ Disease Outbreaks - veterinary
/ Dog Diseases - epidemiology
/ Dog Diseases - transmission
/ Dog Diseases - virology
/ Dogs
/ Epidemiology
/ Genetic diversity
/ Humanities and Social Sciences
/ Influenza
/ Influenza A
/ Influenza A Virus, H3N2 Subtype - genetics
/ Influenza A Virus, H3N2 Subtype - isolation & purification
/ Molecular Epidemiology
/ multidisciplinary
/ Ontario - epidemiology
/ Orthomyxoviridae Infections - epidemiology
/ Orthomyxoviridae Infections - transmission
/ Orthomyxoviridae Infections - veterinary
/ Orthomyxoviridae Infections - virology
/ Outbreaks
/ Phylogenetics
/ Phylogeny
/ Republic of Korea
/ Science
/ Science (multidisciplinary)
2020
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Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
Journal Article
Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
2020
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Overview
The first Canadian H3N2 canine influenza A outbreak involving an Asian-origin H3N2 canine influenza virus (CIV) began in southwestern Ontario, Canada, in late December 2017. More H3N2 CIV cases were identified in central and eastern Ontario between March and October 2018. Based on epidemiological investigation, 5 clusters were identified (C1, C2, C3a, C3b, and C4); however, the origin of infection has only been revealed for epidemiological cluster C1. Here, we use phylogenetic analyses to unravel the links of virus transmission between the 5 epidemiological clusters and the origin of infection for all epidemiological clusters. Our results demonstrate that the Canadian H3N2 CIV sequences were grouped into four distinct phylogenetic clusters with minimal genetic diversity between these clusters. Large scale phylogenetic analysis of H3N2 CIV from around the globe showed that the Canadian CIVs formed a distinct new clade along with CIVs that have been circulating in the USA since 2017–2018 and in China since 2017. This clade shares a common ancestor of Asian origin. This study concludes that the H3N2 CIV outbreak in Ontario was driven by multiple introductions of South Korean/Chinese-origin H3N2 CIVs over 10 months.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/91
/ Animals
/ China
/ Communicable Diseases, Imported - epidemiology
/ Communicable Diseases, Imported - veterinary
/ Communicable Diseases, Imported - virology
/ Disease Outbreaks - veterinary
/ Dogs
/ Humanities and Social Sciences
/ Influenza A Virus, H3N2 Subtype - genetics
/ Influenza A Virus, H3N2 Subtype - isolation & purification
/ Orthomyxoviridae Infections - epidemiology
/ Orthomyxoviridae Infections - transmission
/ Orthomyxoviridae Infections - veterinary
/ Orthomyxoviridae Infections - virology
/ Science
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