Asset Details
Do you wish to reserve the book?
Age-independent increasing prevalence of Human Papillomavirus-driven oropharyngeal carcinomas in North-East Italy
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Age-independent increasing prevalence of Human Papillomavirus-driven oropharyngeal carcinomas in North-East Italy
Do you wish to request the book?
Age-independent increasing prevalence of Human Papillomavirus-driven oropharyngeal carcinomas in North-East Italy
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Age-independent increasing prevalence of Human Papillomavirus-driven oropharyngeal carcinomas in North-East Italy
2020
Overview
HPV-driven oropharyngeal carcinomas (OPCs) show geographical variations with increasing temporal trends in several areas. We investigated their frequency and clinical outcomes within a prospective multicenter cohort study in North-East Italy. A tumor was defined as HPV-driven by using at least two different biomarkers, usually HPV-DNA positivity and p16
INK4A
overexpression. Different survival outcomes were compared among patients with HPV-driven and non-HPV-driven tumors. Overall, 42/130 (32.3%) patients with newly diagnosed OPC during the period 2000–2018 resulted HPV-driven; HPV16 was involved in 37 cases (88%), HPV33 in 3 cases (7%), HPV58 and HPV18 in 1 case each. Over time, HPV-driven cases raised from 16.7% (6/36) during 2000–2006 to 46.1% (24/52) during 2013–2018 (p < 0.001). The increase in HPV-driven OPCs was more marked in females than males (p = 0.010), and the frequency of HPV-driven cases was similar in the different age groups. In comparison to cases with non-HPV-driven tumors, a significantly (p < 0.001) better progression-free and overall survival were recorded among patients affected by HPV-driven OPC. The prevalence of HPV-driven OPC cases has been significantly increasing during the last two decades also in North-East Italy and was associated with favorable outcome. OPCs driven by non-HPV16 oncogenic types were restricted to patients older than 68-yrs.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Cyclin-Dependent Kinase Inhibitor p16 - metabolism
/ Female
/ Humanities and Social Sciences
/ Humans
/ Male
/ Oropharyngeal Neoplasms - epidemiology
/ Oropharyngeal Neoplasms - mortality
/ Oropharyngeal Neoplasms - virology
/ Oropharyngolaryngeal carcinoma
/ Papillomaviridae - pathogenicity
/ Papillomavirus Infections - complications
/ Papillomavirus Infections - epidemiology
/ Papillomavirus Infections - virology
/ Science
/ Survival
/ Tumors
