Asset Details
Do you wish to reserve the book?
Functionalization and antimicrobial evaluation of ampicillin, penicillin and vancomycin with Pyrenacantha grandiflora Baill and silver nanoparticles
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Functionalization and antimicrobial evaluation of ampicillin, penicillin and vancomycin with Pyrenacantha grandiflora Baill and silver nanoparticles
Do you wish to request the book?
Functionalization and antimicrobial evaluation of ampicillin, penicillin and vancomycin with Pyrenacantha grandiflora Baill and silver nanoparticles
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Functionalization and antimicrobial evaluation of ampicillin, penicillin and vancomycin with Pyrenacantha grandiflora Baill and silver nanoparticles
2020
Overview
Some antibiotics have lost their efficacy over common infections and this has led to the search for new antibiotics and chemically altering existing ones for a better control of infectious diseases. In the present study,
Pyrenacantha grandiflora
tubers extracts were conjugated with ampicillin, penicillin, vancomycin and silver nanoparticles and their antimicrobial activity was evaluated against
Escherichia coli
,
Staphylococcus aureus
and
Klebsiella Pneumoniae
. The reactions were confirmed by formation of new functional groups that were identified by Fourier transmission infrared spectroscopy (FTIR). Minimum inhibitory concentrations were determined using the microdilution assay. Minimum bactericidal concentrations and the fractional inhibition concentration index were also determined. FTIR analysis indicated different functional group associated with conjugation. The activity of ampicillin was improved when conjugated with silver nanoparticles against
K. pneumonia
and
E. coli
. Vancomycin showed improvement of activity when conjugated to silver nanoparticles against
K. pneumonia
. Penicillin was improved by acetone extracts and vancomycin showed to be more effective when conjugated with silver nanoparticles and water extracts. The conjugation of
P. grandiflora
with penicillin, ampicillin and vancomycin in the presence of silver nanoparticles improved their biological activities. Therefore, the conjugates are medicinally important and can be used to improve the activity of existing antibiotics.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Acetone
/ Anti-Infective Agents - chemistry
/ Anti-Infective Agents - pharmacology
/ Bacterial Infections - drug therapy
/ Bacterial Infections - microbiology
/ E coli
/ Escherichia coli - drug effects
/ Escherichia coli - pathogenicity
/ Gold
/ Humanities and Social Sciences
/ Humans
/ Klebsiella pneumoniae - drug effects
/ Klebsiella pneumoniae - pathogenicity
/ Metal Nanoparticles - chemistry
/ Science
/ Silver
/ Staphylococcus aureus - drug effects
/ Staphylococcus aureus - pathogenicity
/ Tubers
