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Predominant white matter microstructural changes over gray matter in tinnitus brain
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Predominant white matter microstructural changes over gray matter in tinnitus brain
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Journal Article
Predominant white matter microstructural changes over gray matter in tinnitus brain
2025
Overview
•White matter undergoes microstructural and organizational changes in patients.•Orientation dispersion in forceps minor could mediates cognitive changes in tinnitus patients.•White matter microstructure is more susceptible than gray matter in tinnitus.
To explore microstructure changes across brain white matter and gray matter in tinnitus patients and its effect on neuropsychological performance.
The cross-sectional study used Multi-shell Diffusion Weighted Imaging data and neuropsychological assessment from 48 tinnitus patients and 48 healthy controls. Microstructural features across over white matter and gray matter based on Diffusion Tensor Imaging (DTI) and Neurite Orientation Dispersion and Density Imaging (NODDI) model using Tract-Based Spatial Statistics (TBSS) and Gray Matter-Based Spatial Statistics (GBSS), as well as topological properties were derived from an advanced tractography model in subjects. Brain-neuropsychological performance correlations were analyzed.
Tinnitus patients showed decreased axial diffusivity in forceps minor and right corticospinal tract, increased orientation dispersion in forceps minor, decreased connection strength between the right caudate and pericalcarine, right caudate and superior temporal lobe, and left putamen and cuneus. Global network efficiency and local network efficiency were significantly less in tinnitus patients while feeder connection strength was significantly less in tinnitus patients. The orientation dispersion value mediated the relationship between tinnitus status and Trail Making Test–Part B scores. However, no obvious microstructural changes in gray matter were observed.
Leveraging multi-shell DWI data, the current study indicated that fiber disruption and internal connectivity organizational changes in brain white matter, rather than gray matter, were more susceptible in tinnitus patients. These microstructural changes in white matter could be associated with changes in cognitive function in tinnitus patients.
Publisher
Elsevier Inc,Elsevier Limited,Elsevier
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