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Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression

by Zheng, Chaowen , Lee, Wonseok , Diggle, Karin , Kimura, Yusuke , Ganguly, Souradipta , Liu, Xiao , Brenner, David A. , Szabo, Gyongyi , Tikhanovich, Irina , Mahato, Ram , Rasineni, Karuna , Osna, Natalia A. , Ortega-Ribera, Martí , Li, Siyuan , Sakane, Sadatsugu , Mueller, Sebastian , Kim, Hyun Young , Dhar, Debanjan , Chokshi, Shilpa , McKillop, Iain H. , Kharbanda, Kusum K. , Mueller, Johannes , Kisseleva, Tatiana , Attal, Neha , Weber, Raquel Carvalho Gontijo

in Alcohol / alcohol-associated liver disease / Alcoholic beverages / Animals / Cell activation / Cell death / Cirrhosis / Cytokines / Development and progression / Disease Progression / DNA methylation / Enzymes / Epigenesis, Genetic / Epigenetics / Ethanol / Fatty acid-binding protein / Fatty acids / Fatty liver / Gene expression / Health aspects / hemolysis / hepatic stellate cells / Hepatic Stellate Cells - metabolism / Hepatic Stellate Cells - pathology / Hepatitis / Humans / Inflammation / Liver - metabolism / Liver - pathology / Liver cancer / Liver cirrhosis / Liver diseases / Liver Diseases, Alcoholic - metabolism / Liver Diseases, Alcoholic - pathology / Metabolism / MetAld / Morbidity / Mortality / Organoids / Oxidative stress / Patient outcomes / Steatosis / Stellate cells

2024

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2024

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2024

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Journal Article

Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression

Zheng, Chaowen,

Lee, Wonseok,

Diggle, Karin,

Kimura, Yusuke,

Ganguly, Souradipta,

Liu, Xiao,

Brenner, David A.,

Szabo, Gyongyi,

Tikhanovich, Irina,

Mahato, Ram,

Rasineni, Karuna,

Osna, Natalia A.,

Ortega-Ribera, Martí,

Li, Siyuan,

Sakane, Sadatsugu,

Mueller, Sebastian,

Kim, Hyun Young,

Dhar, Debanjan,

Chokshi, Shilpa,

McKillop, Iain H.,

Kharbanda, Kusum K.,

Mueller, Johannes,

Kisseleva, Tatiana,

Attal, Neha,

Weber, Raquel Carvalho Gontijo

2024

Overview

Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.

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Publisher

MDPI AG

Subject

Alcohol

/ alcohol-associated liver disease

/ Alcoholic beverages

/ Animals

/ Cell activation

/ Cell death

/ Cirrhosis