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Novel Therapeutics for Neonatal Seizures
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Journal Article
Novel Therapeutics for Neonatal Seizures
2021
Overview
Neonatal seizures are a common neurologic emergency for which therapies have not significantly changed in decades. Improvements in diagnosis and pathophysiologic understanding of the distinct features of acute symptomatic seizures and neonatal-onset epilepsies present exceptional opportunities for development of precision therapies with potential to improve outcomes. Herein, we discuss the pathophysiology of neonatal seizures and review the evidence for currently available treatment. We present emerging therapies in clinical and preclinical development for the treatment of acute symptomatic neonatal seizures. Lastly, we discuss the role of precision therapies for genetic neonatal-onset epilepsies and address barriers and goals for developing new therapies for clinical care.
Publisher
Elsevier Inc,Springer International Publishing,Springer Nature B.V
Subject
/ Animals
/ Anticonvulsants - pharmacology
/ Anticonvulsants - therapeutic use
/ Biomedical and Life Sciences
/ Cannabinoids - therapeutic use
/ Chloride
/ Clinical Trials as Topic - methods
/ Electroencephalography - drug effects
/ Electroencephalography - methods
/ Epilepsy
/ GABA Modulators - pharmacology
/ GABA Modulators - therapeutic use
/ Humans
/ Hypoxia
/ Hypoxic-ischemic encephalopathy
/ KCNQ2
/ Neonates
/ Potassium Channels - agonists
/ Potassium Channels - physiology
/ Review
/ Seizures
