Asset Details
Do you wish to reserve the book?
Association of hepatic necrosis with trimethoprim sulfonamide administration in 4 dogs
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Association of hepatic necrosis with trimethoprim sulfonamide administration in 4 dogs
Do you wish to request the book?
Association of hepatic necrosis with trimethoprim sulfonamide administration in 4 dogs
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Association of hepatic necrosis with trimethoprim sulfonamide administration in 4 dogs
1997
Overview
Hepatic necrosis in association with trimethoprim‐sulfonamide (TMS) combination therapy was diagnosed in 4 dogs based on history, clinical presentation, and examination of histopathologic specimens collected postmortem. Duration of TMS therapy prior to onset of clinical signs ranged from 4 to 30 days. The dose of TMS ranged from 18 mg/kg to 53 mg/kg bid. Despite supportive medical therapy, all dogs died or were euthanized due to hepatic failure. This report highlights the potential for hepatotoxicity during TMS therapy. Duration of therapy, type of TMS combination, and dose did not appear related to the development of toxicity. The low number of dogs affected suggests an idiosyncratic drug reaction.
Publisher
Blackwell Publishing Ltd,Oxford University Press
Subject
/ Animals
/ Anti-Infective Agents - adverse effects
/ Anti-Infective Agents - therapeutic use
/ Chemical and Drug Induced Liver Injury
/ CHIEN
/ Dog Diseases - chemically induced
/ DOGS
/ Dose-Response Relationship, Drug
/ Female
/ FOIE
/ HIGADO
/ LIVER
/ Male
/ NECROSE
/ NECROSIS
/ PERRO
/ Pyoderma
/ THERAPEUTIQUE MEDICAMENTEUSE
/ Trimethoprim - adverse effects
/ Trimethoprim - therapeutic use
/ Urinary Tract Infections - drug therapy
